Flirty, flaky party girl Maggie (Cameron Diaz) and plain, dependable lawyer Rose (Toni Collette) are sisters, best friends and bitter rivals who seem to have only two things in common: DNA and the same shoe size.
Only when their love-hate relationship veers toward the hate end of the spectrum – do they accidentally discover they also share a long-lost grandmother (Shirley MacLaine), who enriches their lives and helps them make peace with each other — and themselves!
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